Anavex Life Sciences Corp.

Ticker: AVXL

Class Period Start: 02/01/2022

Class Period End: 01/01/2024

Registration Deadline: 05/13/2024

A securities class action has been filed in the USDC S.D.N.Y. against Anavex Life Sciences Corporation (AVXL) (“Anavex” or the “Company”), on behalf of all persons and entities that purchased or otherwise acquired Anavex securities between February 1, 2022 through January 1, 2024, both dates inclusive (the “Class Period”).


Anavex investigates, manufactures, and markets pharmaceuticals for central nervous system (CNS) disorders. Anavex’s primary product is blarcamesine (Anavex 2-73). Blarcamesine aims to modify specific genetic pathways associated with some CNS disorders. Anavex has sponsored several research studies concerning blarcamesine’s suitability to treat various CNS disorders. One such disorder Anavex has investigated is Rett syndrome, a neurodevelopmental disorder affecting primarily females.


The Complaint alleges that on December 2, 2022, Anavex announced positive topline results from its Phase 2b/3 ANAVEXr2-73-AD-004 clinical trial of oral ANAVEXr2-73 (blarcamesine) for the treatment of mild cognitive impairment (MCI) due to Alzheimer’s disease (AD) and mild AD (collectively known as early AD). ANAVEXr2-73 met the primary endpoints ADAS-Cog1 and ADCS-ADL2 and key secondary endpoint CDR-SB3 with statistically significant results. An analyst questioned the Company’s claim noting “there are several key factors that point us to believe the data is provocative, but not yet compelling, given the choice of statistical analyses and other trial design/conduct `complexifiers’.” Additionally, a biotech journalist commented on the Company’s findings stating “[w]hat sets Anavex apart from all the other biotechs on my radar screen is its habit of shifting the goalposts on clinical trials. Anavex announced “positive” outcomes from studies of its drug called blarcamesine – except the results were derived from efficacy endpoints that were not part of the original study designs.” Following this news, AVXL’s stock price fell by $2.47 per share, or approximately 20% to close at $9.58. Further on January 3, 2024, AVXL announced that results from its Phase 2/3 EXCELLENCE clinical trial for its candidate ANAVEXr2-73 in pediatric patients with Rett syndrome failed to show statistical significance towards its primary endpoints. Biotech analysts commented that “the negative study outcome was never in doubt. Anavex is a serial dissembler of clinical trial results.” Following this news, Anavex’s stock price fell by $3.26 per share, or approximately 35%.


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